Description

2-tert-Butoxy-2-Oxoethylzinc Chloride is a highly reactive organozinc reagent, a crucial building block for the synthesis of complex organic molecules. Its value lies in its ability to facilitate efficient carbon-carbon bond formation under mild conditions, enabling the production of high-value intermediates. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing ketone and ester-containing frameworks.

Application

• As a key reagent in Negishi cross-coupling reactions for the synthesis of complex pharmaceutical intermediates.
• For the preparation of functionalized ketones and esters via acyl anion equivalent chemistry.
• In the research and development of novel active pharmaceutical ingredients (APIs) and agrochemicals.
• As a specialized synthon for fine chemical and advanced material synthesis requiring precise molecular architecture.
• For academic and industrial research in organometallic chemistry and new catalytic methodologies.

Basic Information

Product Name	2-tert-Butoxy-2-Oxoethylzinc Chloride
CAS No.	321745-86-2
Molecular Formula	C6H11ClO2Zn
Molecular Weight	215.99 g/mol
Synonyms	2-(tert-Butoxy)-2-oxoethylzinc chloride; Zinc, [2-(1,1-dimethylethoxy)-2-oxoethyl]chloro-; Chloro[2-(tert-butoxy)-2-oxoethyl]zinc; tert-Butyl glycolate zinc chloride reagent; Glyoxylic acid tert-butyl ester zinc chloride adduct
EINECS	Contact for details

Quality Control

Every batch of 2-tert-Butoxy-2-Oxoethylzinc Chloride is manufactured and analyzed under strict quality protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including titration and spectroscopic analysis, to ensure compliance with high-purity reagent standards. Certificates of Analysis (COA) detailing purity, concentration, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container must be kept sealed and handled under inert conditions to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF or Et2O)	0.5 M - 1.0 M (Typical)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.