Description

2H-1-Benzopyran-6-Carboxaldehyde,3,4-Dihydro-2-Phenyl-,(2S)-(9Ci) is a chiral, enantiomerically pure chromane derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its defined stereochemistry and functional groups, which enable the precise construction of complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential therapeutic agents, particularly in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce the chromane scaffold with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs for novel drug candidates.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring high stereochemical fidelity.
• Academic Research: Utilized in universities and R&D labs for methodological development in organic synthesis and catalysis.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	2H-1-Benzopyran-6-Carboxaldehyde,3,4-Dihydro-2-Phenyl-,(2S)-(9Ci)
CAS No.	319924-94-2
Molecular Formula	C₁₆H₁₄O₂
Molecular Weight	238.28 g/mol
Synonyms	(2S)-3,4-Dihydro-2-phenyl-2H-1-benzopyran-6-carboxaldehyde; (S)-3,4-Dihydro-2-phenyl-2H-chromene-6-carbaldehyde; (S)-6-Formyl-2-phenylchroman; (2S)-2-Phenylchroman-6-carbaldehyde; 319924-94-2; (S)-2-Phenyl-2,3-dihydro-4H-chromene-6-carboxaldehyde; (S)-2-Phenyl-3,4-dihydro-2H-chromene-6-carbaldehyde
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Each lot is characterized using advanced analytical techniques including HPLC, chiral chromatography, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be kept sealed under positive pressure of inert gas after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.