Description

2H-Pyran, Tetrahydro-2-[[(3E)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Buten-1-Yl]Oxy]- is a high-value, functionalized boronic ester derivative that serves as a critical synthetic intermediate. Its molecular architecture, featuring a protected boronate group tethered to a tetrahydro-2H-pyranyl ether, makes it an indispensable building block for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex biaryl and heterobiaryl structures found in drug candidates.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the boronate functionality for structural diversification.
• Materials Science: Building block for the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Ligand & Catalyst Synthesis: Serves as a precursor for creating novel chiral or functionalized ligands used in asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	2H-Pyran, Tetrahydro-2-[[(3E)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Buten-1-Yl]Oxy]-
CAS No.	313342-78-8
Molecular Formula	C15H27BO4
Molecular Weight	282.18 g/mol
Synonyms	(3E)-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl tetrahydro-2H-pyran-2-yl ether; 2-[(3E)-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl]oxy]tetrahydro-2H-pyran; 2-((E)-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxytetrahydro-2H-pyran; THP-protected (E)-butenylboronic acid pinacol ester; (E)-4-(Tetrahydro-2H-pyran-2-yloxy)but-1-enylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2H-Pyran, Tetrahydro-2-[[(3E)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Buten-1-Yl]Oxy]- is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR (1H, 13C, 11B) for structural confirmation, and GC/MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and handle it in a controlled, low-humidity environment. Recommended long-term storage temperature is 2-8°C (refrigerated) or -20°C for extended periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Isomeric Purity (E/Z Ratio by HPLC/GC)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.