Description

4-Chloro-3-Fluorophenylzinc Iodide is a versatile organozinc reagent, a key building block for the formation of carbon-carbon bonds in complex organic synthesis. Its value lies in its high reactivity and selectivity, enabling efficient cross-coupling reactions to introduce the 4-chloro-3-fluorophenyl moiety into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to create novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent in Negishi and other cross-coupling reactions for constructing complex drug candidates, particularly those requiring halogenated aromatic scaffolds.
• Agrochemical Active Ingredient Development: Used to synthesize novel herbicides, fungicides, and insecticides by introducing the difunctionalized phenyl group into lead structures.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with specific electronic or optical properties.
• Custom Chemical and Contract Manufacturing: A key raw material for custom synthesis houses producing bespoke organic compounds for client R&D programs.
• Academic and Industrial R&D: Fundamental research tool in methodology development for new catalytic cross-coupling processes.

Basic Information

Product Name	4-Chloro-3-Fluorophenylzinc Iodide
CAS No.	312693-42-8
Molecular Formula	C6H3ClFZnI
Molecular Weight	312.34 g/mol
Synonyms	(4-Chloro-3-fluorophenyl)zinc iodide; Zinc, (4-chloro-3-fluorophenyl)-, iodide; 4-Chloro-3-fluorobenzenezinc iodide; 4-Chloro-3-fluorophenylzinc iodide solution; 1-Chloro-2-fluoro-4-(iodozincio)benzene; (4-Chloro-3-fluorophenyl)iodozinc; 3-Fluoro-4-chlorophenylzinc iodide
EINECS	Contact for details

Quality Control

Our organometallic reagents are produced and handled under stringent quality protocols. Each batch of 4-Chloro-3-Fluorophenylzinc Iodide undergoes rigorous analysis, including titration for active zinc content and GC/HPLC for purity and solvent composition, to ensure consistency and reliability for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing concentration, purity, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. This compound is easily oxidized (store under inert atmosphere) and highly volatile. It must be stored under a dry, inert atmosphere (argon or nitrogen) at recommended temperatures of 2°C to 8°C. Keep away from heat, sparks, and open flames. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (Typical, variable available)
Assay (Titration)	≥ 95%
Purity (GC/HPLC)	Contact for details
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.