Description

4-Methylbenzylzinc Chloride is a versatile organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 4-methylbenzyl moiety into target molecules during the research and development of new active pharmaceutical ingredients (APIs).
• Negishi Cross-Coupling Reactions: Used as a nucleophilic coupling partner with various aryl, heteroaryl, or vinyl halides/pseudohalides in the presence of palladium or nickel catalysts.
• Agrochemical Manufacturing: Employed in the synthesis of advanced crop protection agents and herbicides that require specific benzyl-substituted structures.
• Ligand and Catalyst Development: Serves as a precursor in the preparation of specialized ligands or organometallic catalysts for asymmetric synthesis.
• Material Science Research: Utilized in the creation of novel organic electronic materials, liquid crystals, or polymers where precise benzyl functionalization is critical.
• Academic & Industrial R&D: A fundamental reagent for methodological studies in organometallic chemistry and new reaction pathway exploration.

Basic Information

Item	Details
Product Name	4-Methylbenzylzinc Chloride
CAS No.	312693-21-3
Molecular Formula	C8H9ClZn
Molecular Weight	205.99 g/mol
Synonyms	(4-Methylbenzyl)zinc chloride; Zinc, chloromethyl-p-tolyl-; p-Tolylmethylzinc chloride; (p-Methylbenzyl)zinc chloride; 4-Methylbenzylzinc chloride solution; 1-(Chlorozinciomethyl)-4-methylbenzene; Chloro(4-methylbenzyl)zinc
EINECS	Contact for details

Quality Control

Our 4-Methylbenzylzinc Chloride is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing, including titration and spectroscopic methods, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing assay, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. This material is easily oxidized and highly volatile; containers must be kept tightly sealed and handled with appropriate precautions to exclude moisture and air.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 0.5 M in specified solvent (e.g., THF)
Purity (Zn basis)	≥ 95%
Solvent	As specified (e.g., Tetrahydrofuran)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.