Description

2-Methylbenzylzinc Chloride is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation, specifically through Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and reliable synthetic intermediates for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for constructing complex, sterically hindered biaryl and alkyl-aryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific substituted aromatic frameworks.
• Negishi Cross-Coupling Reactions: Serves as a superior nucleophilic coupling partner with various aryl, vinyl, and alkynyl halides or triflates in the presence of palladium catalysts.
• Ligand and Catalyst Preparation: Acts as a precursor for the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers with tailored electronic or optical properties.
• Fine Chemical and Flavor/Fragrance Synthesis: Facilitates the production of specific substituted toluene derivatives and other aromatic compounds.

Basic Information

Product Name	2-Methylbenzylzinc Chloride
CAS No.	312693-19-9
Molecular Formula	C8H9ClZn
Molecular Weight	205.99 g/mol
Synonyms	(2-Methylbenzyl)zinc chloride; Zinc, chloromethylphenyl-; (o-Tolylmethyl)zinc chloride; 2-Methylbenzylzinc chloride solution; o-Methylbenzylzinc chloride; Chloro(2-methylbenzyl)zinc; (2-Methylphenyl)methylzinc chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Methylbenzylzinc Chloride is manufactured and tested under stringent quality management protocols to ensure consistency and reliability for critical synthetic applications. Our products undergo rigorous quality testing, including titration for zinc content and analysis of residual halides and moisture, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container must be kept tightly sealed and handled under inert conditions to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms
Moisture (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.