Description

4-Methoxybenzylzinc Chloride is an organozinc reagent, specifically a benzylzinc halide, widely used in organic synthesis for its nucleophilic character. This compound matters as a versatile building block for introducing the 4-methoxybenzyl (PMB) group into target molecules, a common protecting group and structural motif in fine chemical and pharmaceutical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for cross-coupling reactions and nucleophilic additions.

Application

• Key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Nucleophilic reagent in Negishi cross-coupling reactions with aryl or vinyl halides.
• Introduction of the 4-methoxybenzyl (PMB) protecting group for alcohols and carboxylic acids.
• Building block for the preparation of liquid crystals and advanced organic electronic materials.
• Used in agrochemical research for the synthesis of novel herbicides and fungicides.
• Reagent for asymmetric synthesis and the construction of complex natural product analogs.

Basic Information

Product Name	4-Methoxybenzylzinc Chloride
CAS No.	312693-17-7
Molecular Formula	C8H9ClOZn
Molecular Weight	221.99 g/mol
Synonyms	p-Methoxybenzylzinc Chloride; (4-Methoxybenzyl)zinc Chloride; PMB-ZnCl; Zinc, chloro(4-methoxybenzyl)-; 1-(Chlorozinciomethyl)-4-methoxybenzene; 4-Methoxybenzyl Chlorozinc; (4-Methoxyphenyl)methylzinc Chloride
EINECS	Contact for details

Quality Control

Our 4-Methoxybenzylzinc Chloride is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure consistent purity and reactivity, with specifications tailored for research and process-scale applications. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solution concentration is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. Due to its moisture-sensitive and easily oxidized nature, the reagent should be handled under inert conditions using standard Schlenk or glovebox techniques.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.