Description

3-Methoxybenzylzinc Chloride is a versatile organozinc reagent, specifically a benzylzinc halide, widely used in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation through cross-coupling reactions, offering chemists a critical tool for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for introducing the 3-methoxybenzyl moiety.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for the Negishi cross-coupling reaction to create novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides that require specific benzyl-substituted structures.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers with tailored properties.
• Fine Chemical Manufacturing: Applied in the production of specialty fragrances, flavors, and other high-value fine chemicals.
• Academic & R&D Laboratories: A fundamental tool for methodological development in organic chemistry and exploring new synthetic pathways.

Basic Information

Product Name	3-Methoxybenzylzinc Chloride
CAS No.	312693-16-6
Molecular Formula	C8H9ClOZn
Molecular Weight	221.99 g/mol
Synonyms	(3-Methoxybenzyl)zinc Chloride; Zinc, chloromethyl(3-methoxyphenyl)-; 3-Methoxybenzyl Zinc Chloride; m-Methoxybenzylzinc Chloride; (3-Methoxyphenylmethyl)zinc Chloride; 1-(Chlorozinciomethyl)-3-methoxybenzene; 3-Methoxybenzyl Chlorozinc
EINECS	Contact for details

Quality Control

Our 3-Methoxybenzylzinc Chloride is manufactured under strict quality control protocols, typically offered as a solution in tetrahydrofuran (THF) or diethyl ether. Each batch is characterized by NMR spectroscopy and titration to ensure consistent reactivity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, concentration, and impurity profile is provided with every shipment, supporting cGMP and ISO 9001 compliant workflows for our global partners.

Storage

Preserve in a tightly closed container, protected from light. This product is both hygroscopic (moisture-sensitive) and easily oxidized. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. The container should be kept in a cool, dry, well-ventilated area, away from incompatible materials. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zn basis)	≥ 95%
Water Content (Karl Fischer)	< 100 ppm
Solvent	Tetrahydrofuran (stabilized) or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.