Description

5-Fluoro-2-Methylphenylzinc Iodide is a versatile organozinc reagent, specifically an arylzinc halide, widely used in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation through cross-coupling reactions, offering superior functional group tolerance and stability compared to some other organometallic species. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable building block for introducing the 5-fluoro-2-methylphenyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex drug molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated aromatic systems.
• Negishi Cross-Coupling Reactions: Used as a nucleophilic coupling partner with various aryl, heteroaryl, and vinyl halides or triflates in the presence of palladium catalysts.
• Agrochemical Compound Development: Employed in the research and production of advanced herbicides, fungicides, and pesticides where the fluoromethylphenyl group imparts desired biological activity.
• Ligand and Material Science Precursor: Serves as a building block for creating specialized ligands for catalysis or organic electronic materials.
• Functionalized Aromatic Compound Library Synthesis: Critical for medicinal chemistry and discovery research in generating diverse compound libraries for screening.
• Transmetalation Agent: Can be used in sequential cross-coupling strategies or to generate other organometallic species for further transformations.

Basic Information

Product Name	5-Fluoro-2-Methylphenylzinc Iodide
CAS No.	312693-09-7
Molecular Formula	C7H6FIZn
Molecular Weight	277.42 g/mol
Synonyms	(5-Fluoro-2-methylphenyl)zinc iodide; Zinc, (5-fluoro-2-methylphenyl)iodo-; 2-Methyl-5-fluorophenylzinc iodide; 5-Fluoro-o-tolylzinc iodide; Iodo(5-fluoro-2-methylphenyl)zinc; 312693-09-7; (5-Fluoro-2-methyl-C6H3)ZnI
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-2-Methylphenylzinc Iodide is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, concentration, and impurity profile. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is between 2°C and 8°C. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95.0%
Identification (IR)	Conforms to structure
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.