Description

3-Fluoro-4-Methylphenylzinc Iodide is a highly reactive organozinc reagent, specifically an arylzinc halide, widely utilized in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable and versatile building block for introducing the 3-fluoro-4-methylphenyl moiety into target molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the Negishi and other transition-metal-catalyzed cross-couplings to create novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Fine Chemical Manufacturing: Facilitates the production of complex fluorinated aromatic compounds used in flavors, fragrances, and dyes.
• Academic & R&D Laboratories: A valuable tool for methodological development in organic synthesis and exploring new reaction pathways.

Basic Information

Product Name	3-Fluoro-4-Methylphenylzinc Iodide
CAS No.	312693-08-6
Molecular Formula	C7H6FIZn
Molecular Weight	277.42 g/mol
Synonyms	Zinc, (3-fluoro-4-methylphenyl)iodo-; (3-Fluoro-4-methylphenyl)iodozinc; 3-Fluoro-4-methylphenylzinc iodide solution; (4-Methyl-3-fluorophenyl)zinc iodide; Iodo(3-fluoro-4-methylphenyl)zinc; 3-Fluoro-p-tolylzinc iodide; Organozinc reagent 312693-08-6
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Methylphenylzinc Iodide is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, active zinc content, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. This material is hygroscopic (moisture-sensitive) and must be handled in a dry, inert environment to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in THF or as specified
Assay (Titration)	≥ 95% (as C7H6FIZn)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 500 ppm
Related Impurities (GC/HPLC)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.