Description

4-Fluorobenzylzinc Chloride is a highly reactive organozinc reagent, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically through Negishi cross-coupling reactions, which are essential for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key reagent for introducing the 4-fluorobenzyl moiety into active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides containing fluorinated aromatic structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, polymers, and organic electronic materials.
• Negishi Cross-Coupling Reactions: The primary application, facilitating efficient and selective coupling with various aryl, heteroaryl, and vinyl halides.
• Fine Chemical Production: Enables the scalable synthesis of complex, high-value fluorinated fine chemicals and flavors/fragrances.

Basic Information

Product Name	4-Fluorobenzylzinc Chloride
CAS No.	312693-07-5
Molecular Formula	C7H6ClFZn
Molecular Weight	209.96 g/mol
Synonyms	(4-Fluorobenzyl)zinc chloride; Zinc, chlorof(4-fluorophenyl)methyl-; 4-Fluorobenzylzinc chloride solution; (4-Fluorophenylmethyl)zinc chloride; p-Fluorobenzylzinc chloride; 1-(Chlorozincio)methyl-4-fluorobenzene; F-BnZnCl
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzylzinc Chloride is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analysis, including titration for active zinc content, NMR and GC analysis for purity and identity, and tests for residual moisture and halides. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. Due to its hygroscopic and highly volatile nature, the container must be kept sealed and allowed to equilibrate to room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF)	0.5 M (Typical)
Assay (Titration)	≥ 95%
Purity (GC)	≥ 98%
Identification (NMR)	Conforms to structure
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.