Description

3-Fluorobenzylzinc Chloride is a versatile organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable and reactive building block for introducing the 3-fluorobenzyl moiety.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the introduction of the 3-fluorobenzyl group in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorinated benzyl group enhances biological activity.
• Cross-Coupling Reactions: Primarily employed in Negishi-type cross-coupling with various electrophiles (e.g., aryl halides, acid chlorides) to form new C-C bonds.
• Ligand and Catalyst Development: Serves as a precursor in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Utilized in the synthesis of fluorinated organic compounds for electronic materials, liquid crystals, and polymers.
• Fine Chemical Production: Applied in the custom synthesis of complex, high-value fluorinated aromatic compounds for various industrial applications.

Basic Information

Item	Details
Product Name	3-Fluorobenzylzinc Chloride
CAS No.	312693-06-4
Molecular Formula	C7H6ClFZn
Molecular Weight	209.96 g/mol
Synonyms	(3-Fluorobenzyl)zinc chloride; Zinc, chloromethyl-3-fluorophenyl-; 1-(Chlorozinciomethyl)-3-fluorobenzene; 3-Fluorobenzylzinc chloride solution; (3-Fluorophenylmethyl)zinc chloride; 3-Fluorobenzyl zinc chloride; (3-Fluorobenzyl)chlorozinc
EINECS	Contact for details

Quality Control

Our 3-Fluorobenzylzinc Chloride is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized to confirm identity, concentration (typically supplied as a solution in THF or other ethers), and purity, with critical parameters monitored. Certificates of Analysis (COA) detailing assay (by titration), zinc content, and halide content are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is highly volatile, easily oxidized (store under inert atmosphere such as argon or nitrogen), and reacts with strong acids. It must be handled and stored in a cool, dry, well-ventilated area, away from incompatible materials. For solutions, store at recommended temperatures (typically 2-8°C or as specified on the label) and ensure the integrity of the septum seal.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Zinc)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on solvent-free basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.