Description

2-Fluorobenzylzinc Chloride is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation, specifically through Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to introduce the 2-fluorobenzyl moiety into target molecules with high selectivity and yield.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated benzyl groups, leveraging the unique properties of fluorine in drug design.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the 2-fluorobenzyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic applications.
• Negishi Cross-Coupling Reactions: The primary application is as a transmetallation agent to couple with various aryl, vinyl, or alkynyl halides, palladium-catalyzed.
• Custom Fine Chemical Manufacturing: Used for the bespoke synthesis of fluorinated fine chemicals and complex organic molecules for research and development.

Basic Information

Product Name	2-Fluorobenzylzinc Chloride
CAS No.	312693-05-3
Molecular Formula	C7H6ClFZn
Molecular Weight	209.96 g/mol
Synonyms	(2-Fluorobenzyl)zinc chloride; Zinc, chloromethyl-2-fluorophenyl-; (2-Fluorophenyl)methylzinc chloride; 2-Fluorobenzylzinc chloride solution; 1-(Chlorozinciomethyl)-2-fluorobenzene; 2-Fluorobenzyl chloride zinc complex; α-Fluoro-o-tolylzinc chloride; (2-Fluorobenzyl)chlorozinc
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzylzinc Chloride is produced under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Typical quality parameters include titration for active zinc content and quantitative 1H/19F NMR analysis to confirm structure and concentration in solution. A comprehensive Certificate of Analysis (COA) detailing assay, purity, and solvent specifications is provided with each shipment. Our quality management system supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized. Do not expose to air or moisture. For long-term stability, keep the original sealed container in a cool, dry, and well-ventilated area dedicated to flammable organometallic reagents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 95% (as C7H6ClFZn)
Identification (NMR)	Conforms to structure
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.