Description

3,5-Dimethyl-1-Adamantylzinc Bromide is a highly reactive organozinc reagent used in advanced organic synthesis. This compound matters for its ability to introduce the sterically hindered and lipophilic 3,5-dimethyladamantyl group into target molecules, a key step in developing materials with enhanced thermal stability and unique structural properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Used in cross-coupling reactions (e.g., Negishi coupling) to incorporate the adamantyl moiety into drug candidates, potentially improving metabolic stability and lipophilicity.
• Agrochemical Active Ingredient Development: Serves as a building block for creating novel pesticides and herbicides with the robust adamantane core.
• Advanced Material Precursors: Employed in the synthesis of monomers or additives for high-performance polymers, resins, and liquid crystals.
• Catalyst Ligand Synthesis: Facilitates the preparation of specialized phosphine or N-heterocyclic carbene (NHC) ligands bearing the dimethyladamantyl group for catalysis.
• Organic Electronic Material Research: Used to build charge-transporting or emissive core structures in OLED or OFET materials.
• Chemical Biology Probes: Acts as a reagent for labeling or modifying biomolecules to study biological processes.

Basic Information

Product Name	3,5-Dimethyl-1-Adamantylzinc Bromide
CAS No.	312692-99-2
Molecular Formula	C12H19BrZn
Molecular Weight	308.57 g/mol
Synonyms	1-Adamantylzinc bromide, 3,5-dimethyl-; (3,5-Dimethyl-1-adamantyl)zinc bromide; Zinc, bromo(3,5-dimethyl-1-adamantyl)-; 3,5-Dimethyladamant-1-ylzinc bromide; Bromo(3,5-dimethyl-1-adamantyl)zinc; 3,5-Dimethyl-1-adamantylzinc bromide solution
EINECS	Contact for details

Quality Control

Our 3,5-Dimethyl-1-Adamantylzinc Bromide is produced and handled under stringent quality protocols, typically supplied as a solution in tetrahydrofuran or diethyl ether. Each batch undergoes rigorous analysis including NMR (¹H, ¹³C) and titration to confirm identity, concentration, and active zinc content. Certificates of Analysis (COA) with full analytical data are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere), hygroscopic (moisture-sensitive), and highly volatile, this reagent must be stored under a dry, inert gas (argon or nitrogen) atmosphere at recommended temperatures of 2°C to 8°C. The container should be kept in a cool, dry, well-ventilated place, away from heat and ignition sources. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95% (as C12H19BrZn)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.