Description

2,5-Dimethylphenylzinc Iodide is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its primary value lies in enabling highly selective cross-coupling reactions, such as Negishi coupling, to construct complex biaryl and other molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise and efficient methods for carbon-carbon bond formation.

Application

• Key intermediate in Negishi cross-coupling reactions for the synthesis of complex organic molecules.
• Building block for pharmaceutical active ingredients (APIs), particularly in creating sterically hindered biaryl structures.
• Precursor in the development of agrochemicals and specialty fine chemicals.
• Used in materials science for the synthesis of organic semiconductors and liquid crystal compounds.
• Facilitates palladium-catalyzed reactions in medicinal chemistry research and process development.
• Employed in asymmetric synthesis and the preparation of ligand libraries for catalysis.

Basic Information

Product Name	2,5-Dimethylphenylzinc Iodide
CAS No.	312692-96-9
Molecular Formula	C8H9IZn
Molecular Weight	297.45 g/mol
Synonyms	(2,5-Dimethylphenyl)zinc iodide; Zinc, (2,5-dimethylphenyl)iodo-; 2,5-Dimethylphenylzinc iodide solution; (2,5-Xylyl)zinc iodide; 1-Iodo-2,5-dimethylbenzene zinc derivative
EINECS	Contact for details

Quality Control

Our 2,5-Dimethylphenylzinc Iodide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as concentration, purity, and impurity profile. Our quality system is designed to meet the stringent requirements of research and development as well as cGMP environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability. This material is moisture-sensitive (hygroscopic) and easily oxidized; all handling and packaging must be performed under anhydrous, oxygen-free conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in THF or as specified
Assay (Titration)	≥ 95.0%
Identification (IR/NMR)	Conforms to structure
Impurities (HPLC/GC)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.