Description

2 5-Difluorobenzylzinc Chloride is a highly reactive organozinc reagent, specifically a benzylzinc halide, used as a key building block in advanced organic synthesis. Its value lies in enabling efficient carbon-carbon bond formation, particularly in the introduction of the 2,5-difluorobenzyl group into complex molecular architectures under mild conditions. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials industries who require precise functionalization for developing new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs) containing the 2,5-difluorobenzyl moiety, potentially for CNS drugs, kinase inhibitors, and anti-cancer agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and pesticides where the difluorobenzyl group enhances biological activity and metabolic stability.
• Cross-Coupling Reactions: Serves as a nucleophilic coupling partner in Negishi, Kumada, and related transition-metal catalyzed cross-coupling reactions to form biaryl and alkyl-aryl bonds.
• Ligand and Material Science: Employed in the development of specialized ligands for catalysis and as a precursor for functionalized polymers or organic electronic materials.
• Fine Chemical Production: Facilitates the production of complex, fluorinated fine chemicals and flavors & fragrances where specific substitution patterns are required.
• Research & Development: A valuable tool for medicinal and process chemistry research in academic and industrial settings for exploring new chemical entities.

Basic Information

Product Name	2 5-Difluorobenzylzinc Chloride
CAS No.	312692-89-0
Molecular Formula	C7H5ClF2Zn
Molecular Weight	223.87 g/mol
Synonyms	(2,5-Difluorobenzyl)zinc chloride; Zinc, chlorobis(2,5-difluorophenyl)methyl-; 2,5-Difluorobenzylzinc chloride solution; (2,5-Difluorophenyl)methylzinc chloride; 1-(Chlorozinciomethyl)-2,5-difluorobenzene; Benzene, 1-(chlorozinciomethyl)-2,5-difluoro-; Organozinc reagent 312692-89-0
EINECS	Contact for details

Quality Control

Our 2 5-Difluorobenzylzinc Chloride is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing to ensure consistency, purity, and reactivity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as concentration (typically supplied as a solution in THF or ether), zinc content, and halide impurity profile. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. This compound is highly volatile, easily oxidized, and reacts with strong acids and bases. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability. Keep away from heat, sparks, open flames, and oxidizing agents. Use appropriate ventilation and equipment rated for pyrophoric/air-sensitive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Identification (NMR/IR)	Conforms to structure
Zinc Content	Conforms to theoretical
Halide Impurity	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.