Description

3-Chloro-4-Fluorophenylzinc Iodide is a versatile organozinc reagent, a key building block for the formation of carbon-carbon bonds in complex organic synthesis. Its value lies in its high reactivity and selectivity, enabling efficient cross-coupling reactions critical for pharmaceutical and advanced material development. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the 3-chloro-4-fluorophenyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: A crucial reagent in Negishi and other cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs), particularly those containing biaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate halogenated phenyl groups.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED and OFET components, where specific halogenated aromatic units are required.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring functionalized aryl zinc reagents.

Basic Information

Product Name	3-Chloro-4-Fluorophenylzinc Iodide
CAS No.	312624-19-4
Molecular Formula	C6H3ClFZnI
Molecular Weight	312.34 g/mol
Synonyms	(3-Chloro-4-fluorophenyl)zinc iodide; Zinc, (3-chloro-4-fluorophenyl)-, iodide (1:1); 3-Chloro-4-fluorophenylzinc iodide solution; 1-Chloro-2-fluoro-4-(iodozincio)benzene; 312624-19-4; (3-Cl-4-F-C6H3)ZnI
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Fluorophenylzinc Iodide is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure product identity, purity, and consistency for your critical synthesis work. A detailed Certificate of Analysis (COA) including assay (by titration), solvent content, and functional group verification is supplied with each shipment. Our quality system supports compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, this reagent must be stored under an inert gas (argon or nitrogen) in a cool, dry, and well-ventilated area. For extended stability, storage at 2-8°C is recommended. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (organozinc species)
Solvent (GC)	Specified (e.g., THF, Diethyl ether)
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.