Description

(2-Biphenyl)Methylzinc Bromide is a highly reactive organozinc reagent used in advanced organic synthesis. This compound is valued for its role as a versatile building block in cross-coupling reactions, enabling the efficient formation of complex carbon-carbon bonds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing biphenyl and related aromatic frameworks.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing biphenyl motifs found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of advanced crop protection agents and herbicides that require specific biphenyl structures.
• Materials Science Research: Employed in the development of organic semiconductors, liquid crystals, and other functional materials where precise molecular architecture is critical.
• Catalyst Ligand Preparation: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Cross-Coupling Reactions: Primarily used in Negishi-type cross-coupling with aryl halides or triflates to form substituted biphenyls.
• Custom Chemical Synthesis: An essential tool for contract research organizations (CROs) and fine chemical suppliers producing bespoke organic compounds.

Basic Information

Product Name	(2-Biphenyl)Methylzinc Bromide
CAS No.	312624-17-2
Molecular Formula	C₁₃H₁₁BrZn
Molecular Weight	312.52 g/mol
Synonyms	2-(Methylzinc bromide)biphenyl; (2-Phenylphenyl)methylzinc bromide; Biphenyl-2-ylmethylzinc bromide; (2-Biphenylyl)methylzinc bromide; Methyl(2-biphenylyl)zinc bromide; Zinc, bromo(2-biphenylylmethyl)-; (2-Biphenylmethyl)zinc bromide
EINECS	Contact for details

Quality Control

Our (2-Biphenyl)Methylzinc Bromide is produced under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including titration for active zinc content and impurity profiling by NMR and GC/HPLC. A Certificate of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or ether), and test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). For optimal stability, store the sealed reagent bottle under a dry, inert gas (argon or nitrogen) at recommended cold temperatures, typically between 2°C and 8°C. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (organozinc species)
Water Content (Karl Fischer)	< 100 ppm
Free Bromide	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.