Description

2-Chlorobenzylzinc Chloride is a versatile organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation through cross-coupling reactions, offering chemists a critical tool for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for the synthesis of novel compounds and active ingredients.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 2-chlorobenzyl moiety into target molecules during the research and development of new active pharmaceutical ingredients (APIs).
• Negishi Cross-Coupling Reactions: Used as a nucleophilic coupling partner with various aryl, vinyl, or alkynyl halides in the presence of palladium or nickel catalysts to form new C-C bonds.
• Agrochemical Manufacturing: Employed in the synthesis of herbicides, fungicides, and insecticides where the chlorobenzyl group is a critical structural component.
• Ligand and Catalyst Preparation: Serves as a precursor in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Materials Science Research: Utilized in the development of organic electronic materials, such as polymers and small molecules for OLEDs or semiconductors.
• Fine Chemical Production: Applied in the multistep synthesis of specialty chemicals, flavors, and fragrances requiring precise benzylation steps.

Basic Information

Item	Details
Product Name	2-Chlorobenzylzinc Chloride
CAS No.	312624-11-6
Molecular Formula	C7H6Cl2Zn
Molecular Weight	226.39 g/mol
Synonyms	(2-Chlorobenzyl)zinc chloride; Zinc, chlorobenzylchloro-; (2-Chlorophenyl)methylzinc chloride; 1-(Chlorozinciomethyl)-2-chlorobenzene; 2-Chlorobenzylzinc chloride solution; Benzylzinc chloride, 2-chloro-; Chloro(2-chlorobenzyl)zinc
EINECS	Contact for details

Quality Control

Our 2-Chlorobenzylzinc Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including titration for zinc content and GC/HPLC analysis for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and solution concentration (if applicable) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), this reagent must be handled and stored under an inert gas atmosphere (argon or nitrogen) in a cool, dry place. For solutions, standard storage temperature is 2-8°C. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution (typically in THF or ether)
Identification (IR/NMR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (organozinc content)
Zinc Content	Conforms to theoretical
Water Content (Karl Fischer)	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.