Description

2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is a high-value fluorinated pyrimidine derivative, a crucial building block in modern synthetic chemistry. Its trifluoromethyl group and carboxylic acid functionality make it an essential intermediate for creating compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This product is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid
CAS No.	306960-77-0
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)-5-pyrimidinecarboxylic acid; 2-Trifluoromethylpyrimidine-5-carboxylic acid; 5-Carboxy-2-(trifluoromethyl)pyrimidine; 306960-77-0; 2-TFM-Pyrimidine-5-COOH
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for advanced research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.