Description

3-Fluoro-4-Bromo-Acetophenone is a versatile and highly functionalized aromatic ketone building block. This compound is valued for its dual halogen substitution pattern, which enables selective and sequential cross-coupling reactions in complex organic synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the fluorine and bromine atoms confer specific biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, allowing for the introduction of diverse functional groups.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise halogenated aromatic ketone chemistry.

Basic Information

Product Name	3-Fluoro-4-Bromo-Acetophenone
CAS No.	304445-49-6
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	1-(4-Bromo-3-fluorophenyl)ethanone; 4'-Bromo-3'-fluoroacetophenone; 3-Fluoro-4-bromoacetophenone; 4-Bromo-3-fluoroacetophenone; 1-Acetyl-4-bromo-3-fluorobenzene; p-Bromo-m-fluoroacetophenone; 304445-49-6; Ethanone, 1-(4-bromo-3-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Bromo-Acetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.