Description

4-Bromo-1-Ethynyl-2-Fluorobenzene is a high-purity, multi-functional aromatic building block containing bromine, fluorine, and an ethynyl group. This unique combination of reactive handles makes it a critical intermediate for constructing complex molecular architectures in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and materials science industries for applications in drug discovery, crop protection, and the synthesis of specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogen and alkyne functionality.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Click Chemistry: The terminal alkyne group is ideal for Huisgen 1,3-dipolar cycloaddition (click chemistry) to create triazole-linked compounds for chemical biology and drug discovery.
• Fluorine Chemistry Research: Valuable for studying the effects of fluorine introduction on the biological activity and physicochemical properties of lead compounds.

Basic Information

Product Name	4-Bromo-1-Ethynyl-2-Fluorobenzene
CAS No.	302912-33-0
Molecular Formula	C8H4BrF
Molecular Weight	199.02 g/mol
Synonyms	1-Bromo-4-ethynyl-2-fluorobenzene; 2-Fluoro-4-bromophenylacetylene; 4-Bromo-2-fluorophenylacetylene; 2-Fluoro-4-bromoethynylbenzene; 4-Bromo-2-fluoroethynylbenzene; (4-Bromo-2-fluorophenyl)ethyne; 302912-33-0
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Ethynyl-2-Fluorobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and assay. Certificates of Analysis (COA) documenting full specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 96.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.