Description

4-(2,5-Difluorophenyl)-2,2-Dimethyl-5-(4-(Methylsulfonyl)Phenyl)Furan-3(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique furanone core substituted with difluorophenyl and methylsulfonylphenyl groups. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of target drug molecules, especially in oncology and anti-inflammatory research pipelines.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its reactive furanone moiety.
• Research & Development (R&D): Employed in academic and industrial laboratories for the discovery and development of new therapeutic agents.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for client projects.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	4-(2,5-Difluorophenyl)-2,2-Dimethyl-5-(4-(Methylsulfonyl)Phenyl)Furan-3(2H)-One
CAS No.	301692-24-0
Molecular Formula	C19H16F2O4S
Molecular Weight	378.39 g/mol
Synonyms	4-(2,5-Difluorophenyl)-2,2-dimethyl-5-[4-(methylsulfonyl)phenyl]-2,3-dihydrofuran-3-one; 2,2-Dimethyl-5-(4-methylsulfonylphenyl)-4-(2,5-difluorophenyl)dihydrofuran-3-one; 4-(2,5-Difluorophenyl)-2,2-dimethyl-5-(4-methanesulfonylphenyl)furan-3(2H)-one; 301692-24-0; 5-(4-Methanesulfonylphenyl)-4-(2,5-difluorophenyl)-2,2-dimethyl-2,3-dihydrofuran-3-one
EINECS	Contact for details

Quality Control

Our production of 4-(2,5-Difluorophenyl)-2,2-Dimethyl-5-(4-(Methylsulfonyl)Phenyl)Furan-3(2H)-One adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific regulatory or internal quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.