Description

Benzene, 1,2-Difluoro-4-(1E)-1-Propenyl- (9Ci) is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluorobenzene core and propenyl side chain enable precise molecular tuning. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated motifs for enhanced bioactivity, metabolic stability, or material properties.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where fluorine atoms improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers to alter surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for constructing complex, fluorinated biaryl structures.
• Chemical Research: Utilized in academic and industrial laboratories for studying structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	Benzene, 1,2-Difluoro-4-(1E)-1-Propenyl- (9Ci)
CAS No.	301308-13-4
Molecular Formula	C9H8F2
Molecular Weight	154.16 g/mol
Synonyms	1,2-Difluoro-4-[(1E)-1-propen-1-yl]benzene; 4-[(1E)-1-Propen-1-yl]-1,2-difluorobenzene; (E)-1,2-Difluoro-4-(1-propenyl)benzene; (E)-1-Propenyl-1,2-difluorobenzene; (E)-3,4-Difluorostyrene (common misnomer, check structure); 1,2-Difluoro-4-trans-propenylbenzene; 301308-13-4; Benzene, 1,2-difluoro-4-(1E)-1-propenyl-
EINECS	Contact for details

Quality Control

Our Benzene, 1,2-Difluoro-4-(1E)-1-Propenyl- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data including HPLC purity, GC analysis, and NMR confirmation to verify identity and isomeric purity. Certificates of Analysis (COA) detailing all specifications are available upon request for every batch shipped.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.