Description

3',4'-Dimethoxy-2,2,2-trifluoroacetophenone is a specialized trifluoromethylated aromatic ketone, a key building block in advanced organic synthesis. Its molecular structure, featuring both methoxy and trifluoroacetyl groups, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring a trifluoromethyl group to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers where specific electronic properties are desired.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination methodologies and the behavior of fluorine-containing functional groups.

Basic Information

Product Name	3',4'-Dimethoxy-2,2,2-trifluoroacetophenone
CAS No.	300374-83-8
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	1-(3,4-Dimethoxyphenyl)-2,2,2-trifluoroethanone; 3,4-Dimethoxy-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3,4-dimethoxyphenyl)ethanone; 3,4-Dimethoxybenzoyl trifluoromethane; Veratryl trifluoromethyl ketone; TFAP-DM; Trifluoroacetylveratrole
EINECS	Contact for details

Quality Control

Our 3',4'-Dimethoxy-2,2,2-trifluoroacetophenone is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.