Description

2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Corey Lactone is a key, high-value protected intermediate in the synthesis of complex prostaglandins and other bioactive molecules. Its primary value lies in providing a robust, chemically stable handle for stereoselective transformations, enabling the efficient construction of intricate carbon frameworks. This compound is essential for research and development chemists in the pharmaceutical and fine chemical sectors, particularly those working on advanced synthetic routes for active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Prostaglandin Synthesis: A critical chiral building block for the total synthesis of prostaglandin analogs, including misoprostol and other prostaglandin E and F series derivatives.
• Pharmaceutical Intermediate: Serves as a protected lactone intermediate in multi-step syntheses of complex target molecules with biological activity.
• Organic Synthesis Research: Used in academic and industrial R&D for developing new synthetic methodologies and exploring novel chemical space.
• Fine Chemical Production: Employed in the kilogram-scale manufacture of high-purity, specialized chemicals for advanced applications.
• Chiral Pool Utilization: Provides a source of defined stereochemistry for the asymmetric synthesis of natural products and their analogs.

Basic Information

Product Name	2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Corey Lactone
CAS No.	39968-95-1
Molecular Formula	C15H30O3Si
Molecular Weight	286.49 g/mol
Synonyms	tert-Butyldimethylsilyloxy Corey Lactone; TBDMS-Corey Lactone; (3aR,4R,5R,6aS)-5-[(tert-Butyldimethylsilyl)oxy]hexahydro-4-hydroxy-2H-cyclopenta[b]furan-2-one; Corey Lactone TBDMS Ether; 2-[(tert-Butyldimethylsilyl)oxy]-3a,4,5,6a-tetrahydro-4-hydroxy-2H-cyclopenta[b]furan-2-one; Protected Corey Lactone; TBS-Corey Lactone
EINECS	Contact for details

Quality Control

Our 2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Corey Lactone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive analytical data, including chiral purity and impurity profiles, to support your regulatory and process development needs. Certificates of Analysis (COA) detailing identity, assay, and related substances are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.