Description

D-(-)-Norgestrel is a potent synthetic progestin, a key active pharmaceutical ingredient (API) in the steroid hormone class. Its high purity and specific stereochemistry are critical for ensuring the efficacy and safety of final pharmaceutical formulations. This compound is essential for manufacturers in the pharmaceutical industry, particularly for the production of hormonal contraceptives and other hormone replacement therapies.

Application

• Primary Active Pharmaceutical Ingredient (API) in oral contraceptive pills.
• Key component in hormone replacement therapy (HRT) formulations.
• Used in the research and development of new steroidal drugs.
• Reference standard for analytical testing and quality control in pharmaceutical laboratories.
• Intermediate in the synthesis of more complex steroid molecules.

Basic Information

Product Name	D-(-)-Norgestrel
CAS No.	39942-01-3
Molecular Formula	C21H28O2
Molecular Weight	312.45 g/mol
Synonyms	Levonorgestrel Impurity D; (-)-Norgestrel; D-Norgestrel; 13β-Ethyl-17β-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one; (17α)-(-)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one; Wy-5104; NSC-724172
EINECS	254-685-0

Quality Control

Our D-(-)-Norgestrel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assays to confirm stereochemical identity, ensuring it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	-30° to -34° (c=1 in CHCl3)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.