Description

2-Bromo-3-Fluoropropionic Acid is a versatile bifunctional building block containing both bromine and fluorine substituents on a short carboxylic acid chain. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients and functional monomers.

Application

• Pharmaceutical Intermediate: A critical synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the fluorine moiety enhances lipophilicity and target binding.
• Peptide Mimetics & Bioisosteres: Serves as a building block for introducing fluorinated amino acid analogs into peptides to improve stability and bioavailability.
• Liquid Crystal & Polymer Chemistry: Acts as a monomer or precursor for fluorinated polymers and liquid crystal materials with unique electronic and surface properties.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex structures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation strategies and fluorination methodologies.

Basic Information

Product Name	2-Bromo-3-Fluoropropionic Acid
CAS No.	39621-37-9
Molecular Formula	C₃H₄BrFO₂
Molecular Weight	170.96 g/mol
Synonyms	3-Fluoro-2-bromopropanoic Acid; 2-Bromo-3-fluoropropanoic Acid; β-Fluoro-α-bromopropionic Acid; (2-Bromo-3-fluoropropyl)carboxylic Acid; NSC 403796; 39621-37-9; 2-Bromo-3-fluoropropionicacid
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluoropropionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.