Description

3,5-Bis(Trifluoromethyl)Benzenesulfonamide is a high-value, fluorinated aromatic sulfonamide building block. This compound is critical for introducing the lipophilic and electron-withdrawing bis(trifluoromethyl)phenyl moiety into advanced molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for use as a key intermediate in the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of drug candidates, particularly in areas like kinase inhibitors, receptor antagonists, and other small molecule therapeutics where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the sulfonamide group and fluorine atoms contribute to biological activity and environmental persistence profiles.
• Material Science: Serves as a monomer or additive in the production of specialty polymers, coatings, and liquid crystals, leveraging its unique electronic properties and chemical resistance.
• Chemical Research & Development: Employed as a versatile reagent in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) and as a precursor for other functionalized sulfonamides.
• Catalyst & Ligand Preparation: Useful for synthesizing specialized ligands for metal catalysis, where the sulfonamide group can act as a coordinating moiety.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzenesulfonamide
CAS No.	39213-22-4
Molecular Formula	C8H5F6NO2S
Molecular Weight	293.19 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzenesulfonamide; 3,5-Bis(trifluoromethyl)phenylsulfonamide; Benzenesulfonamide, 3,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-3,5-xylylsulfonamide; 3,5-Di(trifluoromethyl)benzenesulfonamide; 3,5-Bis(trifluoromethyl)benzenesulphonamide; 3,5-BTFBSA
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzenesulfonamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.