Description

Ingenol-20-Hexadecanoate CAS NO 39071-33-5 is a semi-synthetic diterpene ester derived from ingenol, a natural compound found in plants of the Euphorbia genus. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity and role as a key intermediate. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutic agents. The product is offered in high-purity grades suitable for advanced chemical synthesis and biological evaluation.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, particularly in oncology and dermatology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel ingenol-based compounds with optimized efficacy and safety profiles.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of ingenol derivatives.
• Biochemical Research: Applied in vitro and in vivo studies to investigate cellular signaling pathways and mechanisms of action.
• Cosmeceutical Development: Explored for potential applications in advanced skincare formulations targeting specific cellular responses.

Basic Information

Product Name	Ingenol-20-Hexadecanoate
CAS No.	39071-33-5
Molecular Formula	C36H56O5
Molecular Weight	568.83 g/mol
Synonyms	Ingenol 20-Hexadecanoate; Ingenol 3-Hexadecanoate; Ingenol-3-hexadecanoate; 20-Hexadecanoyloxyingenol; Ingenol Palmitate; (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6,9,10a-Pentamethyl-1-methylidene-1a,2,5,5a,6,7,8,8a,9,10,10a,10b-dodecahydro-2H-3,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-2-yl hexadecanoate
EINECS	Contact for details

Quality Control

Our Ingenol-20-Hexadecanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified. Due to its light-sensitive and easily oxidized nature, long-term storage is recommended under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and potency. Keep the container in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.