Description

Triptolide CAS NO 38748-32-2 is a diterpenoid triepoxide compound with significant biological activity, primarily isolated from the traditional Chinese medicinal plant *Tripterygium wilfordii* (Thunder God Vine). This potent natural product is valued for its unique and powerful pharmacological properties, making it a critical compound for advanced research and development. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors focused on immunology, oncology, and anti-inflammatory therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel immunomodulatory and anti-cancer drugs.
• Biomedical Research: Used as a potent tool compound in preclinical studies to investigate mechanisms of apoptosis, autoimmune diseases, and inflammation pathways.
• Anti-inflammatory Agent Development: Explored for its efficacy in models of rheumatoid arthritis, lupus, and other chronic inflammatory conditions.
• Oncology Research: Studied for its anti-proliferative and pro-apoptotic effects against various cancer cell lines, including leukemia, pancreatic, and ovarian cancers.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for the identification and quantification of triptolide in raw materials and finished products.
• Natural Product Chemistry: Used in chemical synthesis and structural modification studies to develop analogs with improved efficacy and reduced toxicity profiles.

Basic Information

Product Name	Triptolide
CAS No.	38748-32-2
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	PG490; NSC 163062; (3bS,4aS,5aS,6aS,6bR,7aS,7bS,9R,10aS,10bS,12aS)-3b,4,4a,6a,6b,7a,7b,8,9,10,10a,10b,11,12a-Tetradecahydro-9-hydroxy-6b,7b-dimethyl-5aH-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]furo[3,2-b]oxireno[2',3':7,8]azuleno[5,4-e]oxepin-5a(6H)-one; Triptolid; Tripdiolide
EINECS	Contact for details

Quality Control

Our Triptolide is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data including HPLC purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.