Description

Methyl 2,2-Difluoropropanoate is a versatile fluorinated building block and ester, valued for its unique reactivity imparted by the difluoromethylene group. This compound is essential for introducing fluorine atoms into target molecules, a key strategy in modern pharmaceutical and agrochemical research to modulate properties like metabolic stability and lipophilicity. It serves as a critical intermediate for synthetic chemists and process development scientists in the life sciences and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoroalkyl motifs to enhance drug potency and stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine incorporation improves biological activity and environmental profile.
• Fluorinated Material Precursor: Serves as a monomer or modifier in the development of specialty polymers, coatings, and liquid crystals with enhanced chemical resistance and thermal stability.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and cross-coupling reactions to introduce the -CF2CO2Me group into complex organic frameworks.
• Chemical Research & Development: A valuable tool for medicinal and process chemistry in both academic and industrial R&D settings for exploring new fluorinated compound libraries.

Basic Information

Product Name	Methyl 2,2-Difluoropropanoate
CAS No.	38650-84-9
Molecular Formula	C4H6F2O2
Molecular Weight	124.09 g/mol
Synonyms	Methyl 2,2-Difluoropropionate; 2,2-Difluoropropionic Acid Methyl Ester; Propanoic acid, 2,2-difluoro-, methyl ester; Methyl Difluoropropanoate; Methyl α,α-Difluoropropionate; MDFP
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Difluoropropanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its reactivity with strong alkali, ensure containers are kept tightly sealed and segregated from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.15 g/mL
Boiling Point	~110-115°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.