Description

2-Bromo-2-(4-Nitrophenyl)Acetonitrile is a versatile brominated nitrile building block characterized by its reactive bromine and electron-withdrawing nitrophenyl group. This compound matters for its role as a key synthetic intermediate in constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for applications such as nucleophilic substitution reactions and the synthesis of heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing nitrile or aryl bromide functionalities.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromine atom acts as a reactive handle for further functionalization.
• Material Science Research: Employed in the creation of specialized polymers, liquid crystals, and organic electronic materials due to its rigid aromatic structure.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki, Heck, or Sonogashira couplings to form biaryl or alkyne-linked structures.
• Nucleophilic Substitution: The bromine is readily displaced by various nucleophiles (amines, thiols, alkoxides) to introduce diverse functional groups.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.

Basic Information

Product Name	2-Bromo-2-(4-Nitrophenyl)Acetonitrile
CAS No.	38534-20-2
Molecular Formula	C8H5BrN2O2
Molecular Weight	241.04 g/mol
Synonyms	2-Bromo-2-(4-nitrophenyl)acetonitrile; (4-Nitrophenyl)(bromo)acetonitrile; α-Bromo-4-nitrobenzeneacetonitrile; 2-Bromo-2-(4-nitrophenyl)ethanenitrile; Bromo(p-nitrophenyl)acetonitrile; p-Nitrophenylbromoacetonitrile; 4-Nitro-α-bromobenzyl cyanide; NSC 403079
EINECS	Contact for details

Quality Control

Our 2-Bromo-2-(4-Nitrophenyl)Acetonitrile undergoes rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports cGMP and ISO standards for reliable, consistent supply to critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.