Description

Ascofuranone is a bioactive secondary metabolite belonging to the class of isoprenoid antibiotics. This compound is of significant commercial interest due to its potent inhibitory activity against trypanosome alternative oxidase, making it a valuable research tool and a potential lead compound for therapeutic development. It is primarily utilized by research institutions and pharmaceutical companies engaged in parasitology, drug discovery, and biochemical pathway studies.

Application

• Parasitology Research: As a specific inhibitor of the trypanosome alternative oxidase (TAO), it is a critical tool for studying mitochondrial function and energy metabolism in trypanosomes, the parasites responsible for African sleeping sickness and Chagas disease.
• Drug Discovery & Development: Serves as a lead compound and reference standard in screening programs aimed at developing novel anti-trypanosomal agents targeting unique parasite-specific pathways.
• Biochemical Pathway Analysis: Used in academic and industrial laboratories to investigate and validate the alternative oxidase pathway in various organisms, aiding in fundamental biological research.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for laboratories analyzing related natural products or pharmaceutical compounds.

Basic Information

Product Name	Ascofuranone
CAS No.	38462-04-3
Molecular Formula	C₂₃H₃₄O₅
Molecular Weight	390.51 g/mol
Synonyms	Ascofuranone; Antibiotic X 14931; X 14931; (2E,6E,10E)-14-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl]-2,6,10-trimethyltetradeca-2,6,10-trien-4-one; 14-(3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-2,6,10-trimethyl-2,6,10-tetradecatrien-4-one
EINECS	Contact for details

Quality Control

Our Ascofuranone is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to pale yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.