Description

3-Hydroxy-2-Methylbutanenitrile is a versatile chiral nitrile building block of significant interest in fine chemical synthesis. Its molecular structure, featuring both a hydroxyl and a nitrile functional group, makes it a valuable precursor for the production of complex pharmaceuticals, agrochemicals, and specialty materials. This compound is particularly sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for constructing key intermediates in active ingredient synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral and cardiovascular drugs.
• Agrochemical Synthesis: Used as a building block in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging its nitrile functionality.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other high-value specialty chemicals requiring specific stereochemistry.
• Ligand and Catalyst Development: Employed in research for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Can be utilized to introduce functional groups into polymer chains, modifying properties like adhesion or biocompatibility.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	3-Hydroxy-2-Methylbutanenitrile
CAS No.	38046-46-7
Molecular Formula	C5H9NO
Molecular Weight	99.13 g/mol
Synonyms	2-Methyl-3-hydroxybutyronitrile; 3-Hydroxy-2-methylbutyronitrile; (R,S)-3-Hydroxy-2-methylbutyronitrile; (±)-3-Hydroxy-2-methylbutyronitrile; 2-Methyl-3-oxobutanenitrile (tautomer); 3-Hydroxy-2-methylbutanenitrile; 2-Methyl-3-hydroxybutanenitrile
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-2-Methylbutanenitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay, chiral purity, and impurity profile determination, to ensure it meets the stringent requirements of our global customer base. Certificates of Analysis (COA) detailing specific results for purity, enantiomeric excess, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. Due to its reactivity with strong acids and organic solvents, ensure proper segregation in storage areas.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	Specify required grade (e.g., racemic or specific enantiomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.