Description

Ac-Phg(4-Oac)-Oh is a protected amino acid derivative, specifically an O-acetylated derivative of phenylglycine. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, valued for its role in introducing specific stereochemistry and functional groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptides, active pharmaceutical ingredients (APIs), and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide-based drugs and complex APIs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified phenylglycine residues.
• Chemical Research: Serves as a building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Asymmetric Synthesis: Employed as a precursor or auxiliary in catalytic asymmetric reactions to achieve high enantiomeric purity.
• Bioconjugation: Potential use in the modification of biomolecules for drug delivery systems or diagnostic probes.

Basic Information

Product Name	Ac-Phg(4-Oac)-Oh
CAS No.	37784-27-3
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	N-Acetyl-4-acetoxyphenylglycine; Ac-Phe(4-OAc)-OH; N-Acetyl-O4-acetyl-L-tyrosine; N-Acetyl-4-acetoxy-DL-phenylglycine; 2-Acetamido-2-(4-acetoxyphenyl)acetic acid; (4-Acetoxyphenyl)(acetylamino)acetic acid; Ac-4-AcO-Phe-OH; N-Acetyl-4-acetoxy-phenylglycine
EINECS	Contact for details

Quality Control

Our Ac-Phg(4-Oac)-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). We provide Certificates of Analysis (COA) with detailed specifications for all relevant parameters, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L- or D- isomer as specified)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.