Description

Ethyl 4-Bromocrotonate is a versatile brominated ester building block, primarily valued for its role as a key intermediate in organic synthesis. Its reactive α,β-unsaturated carbonyl structure and bromine substituent make it a crucial precursor for constructing complex molecules through reactions like Michael additions and cross-coupling. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of various active pharmaceutical ingredients (APIs), particularly those containing functionalized butenoate frameworks.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity to introduce bromine and ester functionalities.
• Organic Synthesis Building Block: Employed in Michael addition reactions, palladium-catalyzed cross-couplings (e.g., Suzuki, Heck), and other C-C bond-forming transformations.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialized polymers and advanced organic materials with tailored properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in both academic and industrial R&D laboratories.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Ethyl 4-Bromocrotonate
CAS No.	37746-78-4
Molecular Formula	C6H9BrO2
Molecular Weight	193.04 g/mol
Synonyms	Ethyl (E)-4-Bromobut-2-enoate; 4-Bromocrotonic Acid Ethyl Ester; (E)-Ethyl 4-Bromocrotonate; trans-Ethyl 4-Bromocrotonate; 2-Butenoic acid, 4-bromo-, ethyl ester, (E)-; Ethyl trans-4-bromocrotonate; Ethyl γ-bromocrotonate; Bromocrotonic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromocrotonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, assay, and impurity profiles are available upon request, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (GC/HPLC)	≥ 95.0% (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.