Description

Icosyl 5-Oxo-L-Prolinate is a high-purity, long-chain fatty acid ester derivative of the endogenous metabolite 5-oxoproline (pyroglutamic acid). This specialized compound is valued for its role as a lipophilic prodrug or a key synthetic intermediate in advanced pharmaceutical and cosmetic formulations. It is primarily utilized by R&D and manufacturing teams in the pharmaceutical, nutraceutical, and high-end personal care industries seeking to enhance the bioavailability and skin penetration of active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel prodrugs and active pharmaceutical ingredients (APIs), particularly those targeting improved membrane permeability.
• Cosmetic Actives Carrier: Used in advanced skincare formulations as a penetration enhancer and delivery vehicle for vitamins, peptides, and antioxidants.
• Nutraceutical Formulations: Employed in the development of lipid-based delivery systems for dietary supplements to improve absorption and efficacy.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and metabolic pathway research related to glutathione synthesis and the γ-glutamyl cycle.
• Lipid Chemistry Studies: Utilized in academic and industrial research for studying the properties and reactions of long-chain fatty acid esters of amino acid derivatives.

Basic Information

Product Name	Icosyl 5-Oxo-L-Prolinate
CAS No.	37673-36-2
Molecular Formula	C₂₅H₄₇NO₄
Molecular Weight	425.65 g/mol
Synonyms	Icosyl L-pyroglutamate; Eicosyl 5-oxo-L-prolinate; Eicosyl (S)-5-oxopyrrolidine-2-carboxylate; 5-Oxo-L-proline eicosyl ester; L-Pyroglutamic acid eicosyl ester; 2-Pyrrolidone-5-carboxylic acid, eicosyl ester, L-; Icosyl 5-oxoproline
EINECS	Contact for details

Quality Control

Our Icosyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.