Description

Pyrene 4,5-Oxide is a high-purity, specialized polycyclic aromatic hydrocarbon (PAH) derivative, specifically an arene oxide of pyrene. This compound is of significant value as a critical reference standard and reactive intermediate in advanced chemical research and analytical method development. It is primarily sought after by research institutions, pharmaceutical developers, and environmental testing laboratories for studies in metabolic pathways, mutagenicity, and environmental pollutant analysis.

Application

• Metabolic and Toxicological Research: Used as a standard in studying the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and their DNA adduct formation.
• Environmental Analysis: Serves as a crucial analytical reference standard for the detection and quantification of PAH derivatives in environmental samples (air, water, soil).
• Biomarker Development: Employed in the development and validation of analytical methods (e.g., GC-MS, HPLC) for identifying specific PAH metabolites as exposure biomarkers.
• Organic Synthesis Intermediate: Acts as a reactive precursor or model compound in synthetic organic chemistry for creating more complex molecular structures.
• Mutagenicity and Carcinogenicity Studies: Utilized in in vitro and in vivo assays to investigate the genotoxic potential of PAH epoxides.
• Quality Control & Method Validation: Essential for calibrating instruments and validating analytical procedures in contract research organizations (CROs) and regulatory testing labs.

Basic Information

Product Name	Pyrene 4,5-Oxide
CAS No.	37496-00-7
Molecular Formula	C₁₆H₁₀O
Molecular Weight	218.25 g/mol
Synonyms	4,5-Epoxypyrene; Pyrene-4,5-epoxide; 4,5-Dihydropyrene-4,5-oxide; 4,5-Pyrene oxide; Benzo[def]phenanthrene-4,5-oxide; 4,5-Oxidopyrene; 4,5-Pyrenediol epoxide (precursor name)
EINECS	Contact for details

Quality Control

Every batch of Pyrene 4,5-Oxide is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing purity by HPLC, confirming structure via spectroscopic methods, and reporting impurity profiles. Our quality systems support research requiring traceable and reliable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry, and well-ventilated place. This compound is light-sensitive and should be handled under inert atmosphere when appropriate to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., DMSO, acetone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.