Description

α-Methylmalonate Mono-tert-Butyl Ester is a high-purity, versatile chemical intermediate essential for advanced organic synthesis. Its unique structure, featuring both a reactive methylmalonate moiety and a tert-butyl protecting group, makes it a critical building block for constructing complex molecules with high precision. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for introducing chiral centers and functionalized side chains.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific malonate-derived structures.
• Peptide Mimetics & Prodrug Development: Serves as a precursor for creating peptide analogs and designing prodrugs with enhanced bioavailability.
• Asymmetric Synthesis: Employed in stereoselective reactions to create enantiomerically pure compounds for high-value applications.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Material Science Research: Utilized in academic and industrial R&D for creating novel organic materials and ligands for catalysis.

Basic Information

Product Name	α-Methylmalonate Mono-tert-Butyl Ester
CAS No.	37472-52-9
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	Mono-tert-butyl methylmalonate; 2-Methylmalonic Acid Mono-tert-butyl Ester; tert-Butyl Hydrogen 2-Methylmalonate; 1-(tert-Butoxy)-1-oxopropan-2-yl]acetic Acid; Methylmalonic Acid Mono-tert-butyl Ester; α-Methylmalonic Acid Mono-tert-butyl Ester; (2-Methoxy-2-oxoethyl)propanoic Acid tert-Butyl Ester (related form); MBM-tBu (abbreviation)
EINECS	Contact for details

Quality Control

Our α-Methylmalonate Mono-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The product is compatible with strong alkali and organic solvents but should be kept away from incompatible materials. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.