Description

4-Chloro-2-Methylacetophenone is a versatile chlorinated aromatic ketone that serves as a critical intermediate in advanced organic synthesis. Its unique structure, featuring both a reactive carbonyl group and a chloro substituent on the methylated phenyl ring, makes it a valuable building block for constructing complex molecules. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with anti-inflammatory or central nervous system activity.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides, where the chloromethylacetophenone moiety is incorporated into the final molecule.
• Organic Synthesis Building Block: Employed in Friedel-Crafts acylation reactions and as a starting material for heterocyclic compounds like benzofurans and indoles.
• Fine Chemical Production: Serves as an intermediate in the manufacture of dyes, pigments, and other specialty chemicals.
• Research & Development: Utilized in academic and industrial R&D labs for method development and exploring new synthetic pathways.

Basic Information

Product Name	4-Chloro-2-Methylacetophenone
CAS No.	37074-38-7
Molecular Formula	C9H9ClO
Molecular Weight	168.62 g/mol
Synonyms	1-(4-Chloro-2-methylphenyl)ethanone; 2-Methyl-4-chloroacetophenone; 4-Chloro-2-methylacetophenone; 4'-Chloro-2'-methylacetophenone; p-Chloro-o-methylacetophenone; 4-Chloro-2-methylphenyl methyl ketone; 2-Methyl-4-chlorophenyl methyl ketone
EINECS	253-344-5

Quality Control

Our 4-Chloro-2-Methylacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency meet the high standards required for synthetic intermediates. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment supports your compliance needs in regulated synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40°C - 44°C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.