Description

2-Propen-1-One, 3-(Dimethylamino)-2-Fluoro-1-(4-Methylphenyl)- (9Ci) is a specialized fluorinated α,β-unsaturated ketone derivative, serving as a high-value building block in advanced organic synthesis. Its molecular architecture, featuring a dimethylamino group and a fluorine atom adjacent to the carbonyl, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it is used to introduce key pharmacophores and create novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced organic electronic materials due to its electron-donating and accepting moieties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and fluorescent tags for studying biological processes and enzyme mechanisms.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, including studies on fluorination reactions, Michael additions, and cyclization processes.

Basic Information

Product Name	2-Propen-1-One, 3-(Dimethylamino)-2-Fluoro-1-(4-Methylphenyl)- (9Ci)
CAS No.	37032-46-5
Molecular Formula	C12H14FNO
Molecular Weight	207.24 g/mol
Synonyms	3-(Dimethylamino)-2-fluoro-1-(4-methylphenyl)-2-propen-1-one; 2-Fluoro-3-(dimethylamino)-1-(p-tolyl)prop-2-en-1-one; 2-Fluoro-1-(4-methylphenyl)-3-(dimethylamino)-2-propen-1-one; p-Methyl-2-fluoro-3-dimethylaminoacrylophenone; 37032-46-5; Fluorinated enaminone derivative; DMFP (abbrev.)
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production follows current Good Manufacturing Practice (cGMP) principles where applicable, and each batch is analyzed using advanced chromatographic and spectroscopic techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging are performed under low-light or amber glass conditions to preserve stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.