Description

Dimethyl Threo-2-Bromo-3-Fluorosuccinate is a high-value chiral building block and fluorinated synthetic intermediate. This compound matters for its precise stereochemistry and the strategic introduction of both bromine and fluorine atoms, enabling complex molecular construction in advanced chemical synthesis. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of fluorinated drug candidates, particularly in protease inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides with enhanced activity and environmental profile.
• Asymmetric Synthesis: Serves as a precursor for stereoselective reactions, including nucleophilic substitution and cross-coupling, to construct complex chiral centers.
• Fluorine Chemistry Research: A valuable substrate for studying the influence of fluorine atoms on molecular conformation, reactivity, and metabolic stability.
• Material Science: Potential intermediate in the synthesis of specialty polymers and liquid crystals where fluorine incorporation modifies physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring specific stereochemistry and halogen functionality.

Basic Information

Product Name	Dimethyl Threo-2-Bromo-3-Fluorosuccinate
CAS No.	36875-34-0
Molecular Formula	C6H8BrFO4
Molecular Weight	243.03 g/mol
Synonyms	Dimethyl (2R,3S)-2-Bromo-3-fluorosuccinate; Dimethyl (2S,3R)-2-Bromo-3-fluorosuccinate; Threo-Dimethyl 2-Bromo-3-fluorosuccinate; 2-Bromo-3-fluorosuccinic Acid Dimethyl Ester; Succinic acid, 2-bromo-3-fluoro-, dimethyl ester, (2R,3S)-rel-; (2R,3S)-2-Bromo-3-fluorobutanedioic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our Dimethyl Threo-2-Bromo-3-Fluorosuccinate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (Threo isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.