Description

2,3-Difluorochlorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process engineers for constructing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those containing fluorinated aromatic rings to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorochlorophenyl moiety imparts specific biological activity.
• Liquid Crystal Materials (LCs): Serves as a core building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electro-optical materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into target molecules.

Basic Information

Product Name	2,3-Difluorochlorobenzene
CAS No.	36556-47-5
Molecular Formula	C6H3ClF2
Molecular Weight	148.54 g/mol
Synonyms	1-Chloro-2,3-difluorobenzene; 2,3-Difluorophenyl chloride; 2,3-Difluorochlorobenzene; 2,3-Difluoro-1-chlorobenzene; o,m-Difluorochlorobenzene; Benzene, 1-chloro-2,3-difluoro-; 2,3-DFCB
EINECS	Contact for details

Quality Control

Our 2,3-Difluorochlorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.