Description

5-Chloro-1,2,3-Trifluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for the development of active pharmaceutical ingredients (APIs) and high-performance agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in fluorinated active pharmaceutical ingredients (APIs) where the trifluoromethyl and chloro groups modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated liquid crystals and organic semiconductors, where its structure contributes to desired electronic properties and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the 1,2,3-trifluoro-5-chloro-substituted phenyl moiety into more complex molecules.
• Chemical Research & Development: Essential for medicinal chemistry programs and material science research exploring new compounds with fluorinated aromatic cores.

Basic Information

Product Name	5-Chloro-1,2,3-Trifluorobenzene
CAS No.	36556-44-2
Molecular Formula	C6H2ClF3
Molecular Weight	182.53 g/mol
Synonyms	1-Chloro-2,3,4-trifluorobenzene; 2,3,4-Trifluorochlorobenzene; Benzene, 1-chloro-2,3,4-trifluoro-; 5-Chloro-1,2,3-trifluorobenzene; 2,3,4-Trifluoro-1-chlorobenzene
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-1,2,3-Trifluorobenzene is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.