Description

2-Chloromalonaldehyde is a versatile chlorinated dicarbonyl compound that serves as a key reactive intermediate in organic synthesis. Its unique structure, featuring both an aldehyde and a reactive chloromethyl ketone moiety, makes it a valuable building block for constructing complex heterocyclic and pharmaceutical scaffolds. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various heterocyclic compounds, including pyrazoles, imidazoles, and other nitrogen-containing rings with potential biological activity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators, leveraging its reactivity to form complex molecular architectures.
• Fine Chemical Production: Employed as a building block for dyes, pigments, and advanced organic materials requiring specific chlorinated carbonyl functionalities.
• Cross-coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.
• Chemical Research & Development: Serves as a model compound and starting material in academic and industrial R&D for exploring new synthetic methodologies and reaction mechanisms.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized chelating ligands and organocatalysts due to its ability to form stable complexes with metals.

Basic Information

Product Name	2-Chloromalonaldehyde
CAS No.	36437-19-1
Molecular Formula	C3H3ClO2
Molecular Weight	106.51 g/mol
Synonyms	2-Chloromalondialdehyde; Chloromalonaldehyde; 2-Chloro-1,3-propanedial; 2-Chloropropanedial; Malonaldehyde, 2-chloro-; Propanedial, 2-chloro-; 2-Chloro-1,3-dioxopropane; NSC 163022
EINECS	Contact for details

Quality Control

Our 2-Chloromalonaldehyde is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, well-ventilated area at 2-8°C for long-term stability. This compound is easily oxidized and moisture-sensitive; avoid exposure to air and humidity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.