Description

4-Hydroxymethyl-[1,3,2]Dioxaborolan-2-Ol is a versatile organoboron compound, specifically a cyclic boronic ester, that serves as a crucial building block in modern synthetic chemistry. Its primary value lies in its dual functionality, offering both a protected boronic acid group and a reactive hydroxymethyl handle, making it an essential intermediate for cross-coupling reactions and polymer synthesis. This high-purity chemical is particularly needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and biaryl compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides requiring specific boronate ester functionalities.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, boron-containing resins, and functionalized materials.
• Organic Synthesis Building Block: Employed in medicinal chemistry and academic research for the modular construction of complex organic molecules.
• Ligand & Catalyst Preparation: Utilized in the synthesis of novel ligands for transition metal catalysis and other boron-based catalytic systems.
• Diagnostic Reagent Development: Potential use in developing sensors and diagnostic agents that leverage specific boron-sugar interactions.

Basic Information

Product Name	4-Hydroxymethyl-[1,3,2]Dioxaborolan-2-Ol
CAS No.	36314-25-7
Molecular Formula	C4H9BO4
Molecular Weight	131.92 g/mol
Synonyms	2-(Hydroxymethyl)-1,3,2-dioxaborolan-4-ol; 4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-ol; 1,3,2-Dioxaborolan-2-ol, 4-(hydroxymethyl)-; Pinanediol (Hydroxymethyl)boronate; (Hydroxymethyl)boronic acid pinanediol ester; HMD; Cyclic hydroxymethyl boronic ester
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxymethyl-[1,3,2]Dioxaborolan-2-Ol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can compromise product integrity. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.