Description

cis-Cyclobutane-1,2-Diol CAS NO 35358-33-9 is a high-purity, versatile chiral building block featuring a strained cyclobutane ring with two adjacent hydroxyl groups in the cis configuration. This unique molecular geometry makes it a valuable intermediate for synthesizing complex pharmaceuticals, advanced materials, and fine chemicals. It is particularly sought after by research and development teams in the pharmaceutical, agrochemical, and specialty polymer industries for constructing novel molecular architectures with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring rigid, strained ring systems.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the cis-diol moiety can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Incorporated into specialty polymers to modify rigidity, biodegradability, or to introduce reactive sites for further functionalization.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new reaction pathways and constructing complex natural product analogs.
• Cross-linking Agent: Potential use in creating cross-linked networks for resins or hydrogels due to its bifunctional hydroxyl groups.

Basic Information

Product Name	cis-Cyclobutane-1,2-Diol
CAS No.	35358-33-9
Molecular Formula	C4H8O2
Molecular Weight	88.11 g/mol
Synonyms	(1R,2S)-Cyclobutane-1,2-diol; (1S,2R)-Cyclobutane-1,2-diol; cis-1,2-Cyclobutanediol; (1R,2S)-1,2-Cyclobutanediol; (1S,2R)-1,2-Cyclobutanediol; rac-cis-Cyclobutane-1,2-diol; Cyclobutane-cis-1,2-diol
EINECS	Contact for details

Quality Control

Our cis-Cyclobutane-1,2-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the highest standards of purity and consistency. Certificates of Analysis (COA) detailing specific batch results for identity, purity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.