Description

Simalikalactone D CAS NO 35321-80-3 is a bioactive quassinoid compound, a secondary metabolite primarily isolated from the medicinal plant *Simarouba amara*. This compound is of significant interest due to its potent and selective biological activities, particularly its antimalarial and cytotoxic properties. It is a critical reference standard and research material for pharmaceutical R&D, natural product chemistry, and the development of novel therapeutic agents targeting parasitic diseases and cancer.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and standardization of herbal extracts and antimalarial drug formulations.
• Antimalarial Research: Serves as a key lead compound and pharmacological probe in the study of *Plasmodium* species, aiding in the discovery of new antimalarial mechanisms and drugs.
• Oncology and Cytotoxicity Studies: Investigated for its antiproliferative effects against various cancer cell lines in preclinical research for potential anticancer drug development.
• Natural Product Chemistry & Isolation: Acts as a marker compound for the identification, authentication, and phytochemical profiling of *Simarouba* species and related genera.
• Biochemical Pathway Analysis: Utilized in research to elucidate biosynthetic pathways of quassinoids and their role in plant defense mechanisms.
• Academic & Institutional Research: Essential for universities and research institutes conducting studies in pharmacology, phytochemistry, and tropical disease therapeutics.

Basic Information

Product Name	Simalikalactone D
CAS No.	35321-80-3
Molecular Formula	C₂₅H₃₄O₉
Molecular Weight	478.53 g/mol
Synonyms	Simalkalactone D; 15-Desacetyl-12-deoxyglaucarubinone; Quassinoid D; NSC 165101; 2H,6H-Pyrano[3,2-b]xanthen-6-one, 1,2,3,4,4a,5,7,8,13,13b-decahydro-4a,7-dihydroxy-3,6,9-trimethyl-11-methylene-, [2R-(2α,3β,4aβ,6α,7α,13bα)]-; Glaucarubinone analog
EINECS	Contact for details

Quality Control

Our Simalikalactone D is produced under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standards, and custom purification to meet specific pharmacopeial or research-grade specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider storage under inert atmosphere at -20°C. The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.