Description

tert-Butyl Diazoacetate is a versatile and highly reactive diazo compound used as a key building block in organic synthesis. Its primary value lies in its ability to serve as a carbene precursor for cyclopropanation reactions and as a source of the tert-butoxycarbonyl (Boc) protected glycine synthon. This makes it an indispensable reagent for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules, natural products, and novel materials.

Application

• Pharmaceutical Intermediates: A critical precursor for the synthesis of amino acid derivatives, β-lactam antibiotics, and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides through cyclopropanation and other C-H insertion reactions.
• Material Science: Employed in the creation of specialized polymers and functional materials via carbene-based cross-linking or surface modification.
• Catalysis Research: Acts as a standard reagent for developing and testing new metal-catalyzed transformations, such as those involving rhodium or copper.
• Natural Product Synthesis: Facilitates the construction of complex, biologically active natural products that require cyclopropane rings or specific ester functionalities.
• Peptide Chemistry: Serves as a protected glycine equivalent for the solid-phase or solution-phase synthesis of peptides and peptidomimetics.

Basic Information

Product Name	tert-Butyl Diazoacetate
CAS No.	35059-50-8
Molecular Formula	C6H10N2O2
Molecular Weight	142.16 g/mol
Synonyms	2-Diazoacetic Acid 1,1-Dimethylethyl Ester; (tert-Butoxycarbonyl)diazomethane; t-Butyl Diazoacetate; Diazoacetic Acid tert-Butyl Ester; tert-Butyl 2-Diazoacetate; BDA; Boc-diazomethane; N2CHCO2tBu
EINECS	Contact for details

Quality Control

Our tert-Butyl Diazoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, IR, and HPLC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. This product is light-sensitive (store away from light) and should be handled with appropriate precautions due to its diazo functionality. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.